Discovery of HSPB1 as a Novel Genetic Marker for Predicting Poor Survival of Stomach Cancer Patients
Abstract – The HSPB1 gene encodes heat shock proteins and acts as a chaperone by regulating processes and maintaining competent proteins induced in response to stresses and injuries. The expression or alteration of this HSPB1 gene can be associated with poor survival rates by promoting and proliferating metastasis. Although this gene displays an increase in tumor growth in a variety of cancers, gene alteration of HSPB1 has not been reported for stomach cancer. Here, we analyzed DNA, mRNA, and clinical data of 1512 patient samples from 7 different stomach cancer studies by cBioPortal. Our data showed that gastric cancer patients with the HSPB1 amplified gene had a significantly lower survival rate (median survival = 14.3) than the patients with the HSPB1 non-amplified gene (median survival = 31.0) (p = 0.033). The data additionally showed the median survival rate of the group having a high expression of the HSPB1 gene (median survival of about 21.2 months) was lower than the group with a low expression of the HSPB1 gene (median survival of about 107.7 months). Overall, patients with a non-amplified HSPB1 gene had a higher percentage of papillary stomach adenocarcinoma.